New Reasons to Avoid Mixing Juice and Medicine

Patients often are warned against taking certain pills with grapefruit juice, which can turn normal doses of a drug into a toxic overdose. Now, researchers have raised a new concern: grapefruit, orange and apple juices may also block the effects of some drugs, wiping out any potential benefit to patients, according to a new study.
So far, the investigators have found that grapefruit, orange and apple juices reduce absorption of the anticancer drug etoposide; certain beta blockers used to treat high blood pressure; cyclosporine, used to prevent rejection of transplanted organs; and certain antibiotics. Additional drugs are likely to be added to the list, said David G. Bailey, a professor of clinical pharmacology at the University of Western Ontario.
“This is just the tip of the iceberg,” Dr. Bailey said. “I’m sure we’ll find more and more drugs that are affected